do you get trick or treaters?

I live in a warehouse topped with lightly domesticated crows. I have a large dog who is forbidding but a pushover, and I am me.

Which is to say, if I do get trick-or-treaters…

They are brave and therefore deserving of their full-sized candy bars.

I’m not an expert on this, but doesnt semen also contain protein? Does this mean that swallowing it can turn you into a cannibal?

simonalkenmayer:

Semen is the germ line only and has extremely limited protein expression. The existence of porn stars in good health is proof that there is something about the completed human protein that uniquely triggers the prion mistake.

I will add what my geneticist associate says:

“Sperm or egg (the cells that make the embryo) don’t express the full proteome, especially not neural proteins that may be especially dangerous. Eggs are probably more dangerous as they express many more proteins, but sperm expresses and extremely limited complement – probably safe to eat, though icky =)”

anyilherron:

simonalkenmayer:

anyilherron:

systlin:

simonalkenmayer:

Kuru, because apparently, you don’t understand why cannibalism is a terrible idea.

Kuru is the name of the brain wasting disease that is caused by humans eating humans. Its counterpart, another prison disease called Mad cow, is due to cows eating other cows.

Kuru can be contracted by eating ANY human tissue, including, but NOT EXCLUSIVELY the brain.

When a species consumes proteins, the body disassembles them and folds them up into the shape they need to be to be used for human repair. The body has a system for being able to tell your human proteins from the foreign proteins, so that it does not metabolize you. When a species consumes another member of its own kind, the body cannot tell what it is doing. It cannot tell if it is consuming a foreign protein or a like protein. This leads to errors in how these proteins are digested, how they’re allocated to repairs, etcetera. This means that a protein that is unusable gets shuffled off to a part of the body, absorbed by a cell…and then it sits there.

This protein, called a prion, causes a cataclysmic chain reaction in the cell, which eventually shuts down the cell completely. This is not so terrible if it happens in a limb, but when the brain absorbs the protein, the dead dendrite interrupts memories, nerve signals, and so forth. The chain firing of neurons ceases and cells around it die. As more cells die, the wasting occurs, resulting in eventual death.

The MYTH results from the aggregation of these proteins, my friends. Kuru doesn’t spontaneously appear! It occurs only when these proteins begin to lodge in the body. If person A eats Persons B-F they will eventually contract Kuru. If person G eats Person A, then they have their own proteins from eating people, now aggregated (this means accumulated) along with the prions of Person A. So over time, the brains of cannibals are simply an absolute mess of prions, from which you will almost certainly contract Kuru.

It is a cumulative medical condition.

So once again, for the people in the back: KURU DOESNT SPONTANEOUSLY APPEAR. IT BEGINS WHEN A HUMAN EATS ANOTHER AND CONTINUES TO AGGREGATE IN TISSUES. YOU CAN CONTRACT KURU FROM EATING ANY HUMAN TISSUE.

But Simon, you say…How does the math work?

It is cumulative risk. As I said in another post today on this topic: if you eat a non-cannibal person one time, the likelihood of you contracting prion disease is small. If you keep eating people, the risks increase, particularly if you are eating cannibals. All skydiving deaths occur only in the group of people who make multiple jumps. The more you do something, the more likely you are to die while doing it.

Does this make sense?

Have I cleared up this fucking appalling discrepancy in logic?

I cannot believe I have to do this, but here it is.

DO NOT EAT PEOPLE. IT IS BAD FOR YOU.

Just leave it for me.

Don’t Eat People if you Are A People, People.

If you find yourself with a fresh corpse, just leave it out with a nice ‘bon appitit’ sign for your local Simon or Cousin.  

ooc: OP, you’ve got some of it right, and some of it wrong.

On Kuru itself, you’re pretty well right as far as I understand it – except fo rthe part about how it kills you. Prion diseases cause normal, functional proteins in your own body to misfold and that misfolding causes disease by killing the cells where it happens. In humans, this only happens to one kind of protein that we know of, one’s that’s called PrP (for Prion Protein). The misfolded protein messes up the cell in ways we don’t fully understand. It’s transmitted by eating people who have the prion in them. In that way, it’s similar to Bovine Spongiform Encephalopathy (BSD), also called Mad Cow Disease – save that in BSE, the misfolded protein was made by the cow, not by a human. How does it kill the cells? As far as I can tell, we don’t know yet, but you’re absolutely right that brain cells dying is worse than, say, skin cells.

However, on the specifics of transmission on the molecular level, you’re wrong. Humans break down EVERY protein we eat; we don’t just refold one that’s already assembled. In the stomach and small intestine, proteases like trypsin and chymotrypsin literally chop the proteins apart into small chunks. (for further info, see https://en.wikipedia.org/wiki/Digestive_enzyme). This process doesn’t differentiate between human proteins and any other – those things are scissors. They see a certain sequence in a protein, and they cut the protein there. Once a protein has been cut into its building blocks, the cells of the small intestine pull those in and help distribute the building blocks to the rest of the body; each body cell then converts the building blocks into proteins we need.

How, then, do prions get passed through food? The answer, is (surprise!) not clear. One thing that may help is that prion proteins are usually highly resistant to proteases, meaning that perhaps they can pass through the stomach whole (unlike most proteins!) and then get itno our body from there.

tl;dr We cut apart proteins in our digestive system, so saying non-functional proteins get in is incorrect; prions may be an exception to that because they’re resistant to our molecular scissors.

And yes, I’m being very picky.

I appreciate the correction immensely. My understanding was obtained through conversations with geneticists and biologists, and I am not one of these. I was aware of the “scissors” but was also seeking to put the science into a much more simple form so that it would transmit well, which you did far better. This is why you are the scientist and I am the people-eating monster who sits at a computer dealing with Nazis. Thank you for providing specificity, as the point is truth, not rubbish.

ooc: Thanks for your kind reply! Like I said, large parts of it were quite true. ^^ And your point of cannibalism being unhealthy and the vector for nasty brain disease is spot-on – and as I was a molecular biologist AND a biology teacher I couldn’t really help myself. ^^;

If you want a better theory of transmission I read an article that suggests that my hypothesis of prions being resistant to proteases was wrong, and infection may actually occur in the mouth (https://www.ncbi.nlm.nih.gov/pubmed/16575798). Basically, a study was performed in sheep where alimentary fluid – aka saliva, stomach juices, and intestinal juices – can digest the prion significantly, leaving only trace amounts. (https://www.ncbi.nlm.nih.gov/pubmed/16575799/) However, prions were found very quickly in intestinal absorbing cells – the things that take up nutrients from the gut – and so it’s possible that they get in very early on, perhaps even through our mouth.

tl:dr thanks for being cool and hey look at this science I found and am postulating on!

That is fascinating! I wonder if it is because the mouth is an unprotected mucal membrane? Or would it be do to entering the blood stream via the gums? I’ve often wondered about that, because I know from personal experience that stomach acid is extremely caustic, and I found myself wondering how on earth prions could survive such an environment. I am Old however, and so often I find that science enters a fuzzy realm for me of slightly mystically pure. Which is not to say it seems magical to me, but to say that I am rather comfortable with leaving it an unknowable. I enjoy when things are finally proven, but in the interim, I stare at the puzzle and say, “Well, the outcome seems a sure thing, so I will just let it be.”

This is likely due to how very young science is. It is always new, and I am somewhat swept over by it.

Again, thank you for the addition to the post. I’m very pleased you did so.

THOSE FUCKERS IN THE COMMENTS ARE SUCH BITCHES WOMEN PEOPLE ARE ALWAYS WHINING AND MOANING ABOUT INJUSTICE AND OTHER BULLSHIT BUT THEY ACT ALL HIGH AND MIGHTY WHEN A DUDE WANTS TO BONE AND HE’S EARNED IT. THEY NEED TO BE TAUGHT A LESSON ABOUT THE WAY THIS WORKS SO HOPEFULLY THE ANGRY PENIS GETS WHAT’S HIS.

hedge-born-fluffy-wolf:

simonalkenmayer:

hedge-born-fluffy-wolf:

simonalkenmayer:

youcantseebutimmakingaface:

simonalkenmayer:

youcantseebutimmakingaface:

simonalkenmayer:

systlin:

simonalkenmayer:

thisishowyoufightawar:

simonalkenmayer:

My gentle readers…

I hope you take my meaning when I say:

Cry “Havoc” and let slip the dogs of war.

And to you, my cowardly antagonist…

If you weren’t so bloody stupid, I’d laugh, and if you weren’t so extremely incautious as to hand me your IP address, and therefore your street address…

I’d be vexed.

So thank you for that, my white-bellied swine.

Were they really that stupid to say something like this to a man eating monster

really now

You’d be terribly surprised and dismayed if I told you how often it happens or how much money I spend per year on sophisticated software programs to locate them.

Simon, you were right, the human race has NO survival instinct.

Particularly Bulgarians.

*Vulgarians.

Now now…

The vast majority of Bulgarians are lovely people and their cooking techniques are wonderful. As for the ones who sit in movie theaters and send angry misogynistic messages…ill-mannered.

*shakes head*

In the shadow of the “Palace of Culture”. It really does astound me.

People ask “Simon, what keeps you going after so long?”

The answer is: the tremendous variety and creativity with which humans make utter fools of themselves.

I’m sure 99.9% of Bulgarians are charming. This dude, no. Denied. Go and wander shunned by your fellow people, that’s the only thing he has earned.

PS you can’t earn sex. You either get consent or you suck it up and make friends with your hand.

And “putting in effort” on a female is not done to “earn” her affections. It’s done from a place of love and devotion.

Capitalism, how it does haunt the human race.

I have many words for that Anon. Most of which aren’t fit for polite society.

Ahhh…

but my dear, you are hedge-born.

Well by your leave then. Warning: I don’t usually do this but here we go. What sort of shit for brains caveman comes onto the blog of a people eating monster to insult women by implying that we owe you a fucking thing Anon? Context clue seen above. We owe you nothing you limp dick sonuvabitch. I am willing to bet that you are some sad little wrastle who gets off on rape fantasies. You sicken me. You are a stain. A blight on humanity. Your existence is a joke. Your mother should have swallowed you. Your father should have left you in a sock under his bed. Crawl back under whatever bridge you hail from and let the rest of the civilised world forget that sad little men like you exist.

image

whY don’T thE femS likE uS nO morE thougH? theY alL turninG tO lesbianesE tO avoiD uS! wE aren’T sO baD wE jusT wanT lovE 💖

simonalkenmayer:

Yes…

Bait me some more. Because that’s been shown to work out well in the past.

But so be it. Firstly, women don’t turn into lesbians. They either are or aren’t or were always open to experimentation, or weren’t, you dribbling clod. Secondly, what you want isn’t love. What you want is to get your pintel polished. You want no emotional investment at all, but expect the female to hand over her body and the private corners of her mind. Thirdly, anyone who speaks as you do is “so bad” and deserves to rot in a furrow rather that to stick his blind meat in anything living.

Israel. I find that a bit surprising.

whY don’T thE femS likE uS nO morE thougH? theY alL turninG tO lesbianesE tO avoiD uS! wE aren’T sO baD wE jusT wanT lovE 💖

Yes…

Bait me some more. Because that’s been shown to work out well in the past.

But so be it. Firstly, women don’t turn into lesbians. They either are or aren’t or were always open to experimentation, or weren’t, you dribbling clod. Secondly, what you want isn’t love. What you want is to get your pintel polished. You want no emotional investment at all, but expect the female to hand over her body and the private corners of her mind. Thirdly, anyone who speaks as you do is “so bad” and deserves to rot in a furrow rather that to stick his blind meat in anything living.

THOSE FUCKERS IN THE COMMENTS ARE SUCH BITCHES WOMEN PEOPLE ARE ALWAYS WHINING AND MOANING ABOUT INJUSTICE AND OTHER BULLSHIT BUT THEY ACT ALL HIGH AND MIGHTY WHEN A DUDE WANTS TO BONE AND HE’S EARNED IT. THEY NEED TO BE TAUGHT A LESSON ABOUT THE WAY THIS WORKS SO HOPEFULLY THE ANGRY PENIS GETS WHAT’S HIS.

hedge-born-fluffy-wolf:

simonalkenmayer:

youcantseebutimmakingaface:

simonalkenmayer:

youcantseebutimmakingaface:

simonalkenmayer:

systlin:

simonalkenmayer:

thisishowyoufightawar:

simonalkenmayer:

My gentle readers…

I hope you take my meaning when I say:

Cry “Havoc” and let slip the dogs of war.

And to you, my cowardly antagonist…

If you weren’t so bloody stupid, I’d laugh, and if you weren’t so extremely incautious as to hand me your IP address, and therefore your street address…

I’d be vexed.

So thank you for that, my white-bellied swine.

Were they really that stupid to say something like this to a man eating monster

really now

You’d be terribly surprised and dismayed if I told you how often it happens or how much money I spend per year on sophisticated software programs to locate them.

Simon, you were right, the human race has NO survival instinct.

Particularly Bulgarians.

*Vulgarians.

Now now…

The vast majority of Bulgarians are lovely people and their cooking techniques are wonderful. As for the ones who sit in movie theaters and send angry misogynistic messages…ill-mannered.

*shakes head*

In the shadow of the “Palace of Culture”. It really does astound me.

People ask “Simon, what keeps you going after so long?”

The answer is: the tremendous variety and creativity with which humans make utter fools of themselves.

I’m sure 99.9% of Bulgarians are charming. This dude, no. Denied. Go and wander shunned by your fellow people, that’s the only thing he has earned.

PS you can’t earn sex. You either get consent or you suck it up and make friends with your hand.

And “putting in effort” on a female is not done to “earn” her affections. It’s done from a place of love and devotion.

Capitalism, how it does haunt the human race.

I have many words for that Anon. Most of which aren’t fit for polite society.

Ahhh…

but my dear, you are hedge-born.

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